Active Ingredient History
Midazolam, previously marketed under the trade name Versed, is a medication used for anesthesia, procedural sedation, trouble sleeping, and severe agitation. Midazolam is a short-acting benzodiazepine central nervous system (CNS) depressant. Pharmacodynamic properties of midazolam and its metabolites, which are similar to those of other benzodiazepines, include sedative, anxiolytic, amnesic and hypnotic activities. Benzodiazepine pharmacologic effects appear to result from reversible interactions with the γ-amino butyric acid (GABA) benzodiazepine receptor in the CNS, the major inhibitory neurotransmitter in the central nervous system. The action of midazolam is readily reversed by the benzodiazepine receptor antagonist, flumazenil. Data from published reports of studies in pediatric patients clearly demonstrate that oral midazolam provides safe and effective sedation and anxiolysis prior to surgical procedures that require anesthesia as well as before other procedures that require sedation but may not require anesthesia. The most commonly reported effective doses range from 0.25 to 1 mg/kg in children (6 months to <16 years). The single most commonly reported effective dose is 0.5 mg/kg. Time to onset of effect is most frequently reported as 10 to 20 minutes. The effects of midazolam on the CNS are dependent on the dose administered, the route of administration, and the presence or absence of other medications. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Abscess (Phase 4)
Acute Lung Injury (Phase 4)
Acute Pain (Phase 3)
Adenoidectomy (Phase 3)
Aggression (Phase 4)
Airway Extubation (Phase 3)
Airway Obstruction (Phase 4)
Alcoholism (Phase 4)
alpha 1-Antitrypsin Deficiency (Phase 1)
Alzheimer Disease (Phase 1)
Ambulatory Surgical Procedures (Phase 4)
Amnesia (Phase 1)
Amyotrophic Lateral Sclerosis (Phase 1)
Analgesia (Phase 4)
Analgesia, Patient-Controlled (Phase 4)
Analgesics (Phase 4)
Analgesics, Opioid (Phase 4)
Anemia (Phase 1)
Anemia, Sickle Cell (Phase 1)
Anesthesia (Phase 4)
Anesthesia and Analgesia (Phase 3)
Anesthesia, Epidural (Phase 4)
Anesthesia, General (Phase 4)
Anesthesia, Inhalation (Phase 4)
Anesthesia, Local (Phase 3)
Anesthesia, Spinal (Phase 4)
Anterior Cruciate Ligament Injuries (Phase 2)
Anti-Anxiety Agents (Phase 4)
Anxiety (Phase 4)
Anxiety Disorders (Phase 4)
Arthritis, Rheumatoid (Phase 1)
Arthroplasty (Phase 4)
Arthroplasty, Replacement, Knee (Early Phase 1)
Aspergillosis (Phase 1)
Asthma (Phase 4)
Atherosclerosis (Phase 1)
Bacterial Infections (Phase 1)
Bariatric Surgery (Phase 4)
Behavior (Phase 2)
Biological Availability (Phase 1)
Bipolar Disorder (Phase 4)
Bone Marrow Cells (Phase 4)
Borderline Personality Disorder (Phase 2)
Brain Diseases (Phase 4)
Brain Injuries (Phase 4)
Brain Injuries, Traumatic (Phase 4)
Brain Ischemia (Phase 2)
Brain Neoplasms (Phase 1)
Breast Neoplasms (Phase 3)
Breech Presentation (Phase 3)
Bronchoscopy (Phase 4)
Bunion (Phase 2)
Bupivacaine (Early Phase 1)
Burns (Phase 2/Phase 3)
Cannabis (Phase 4)
Carcinoma (Phase 1)
Carcinoma, Hepatocellular (Phase 2)
Carcinoma, Non-Small-Cell Lung (Phase 4)
Carcinoma, Renal Cell (Phase 4)
Cardiovascular Diseases (Phase 1)
Cataract (Phase 2)
Central Nervous System Diseases (Phase 2)
Central Nervous System Neoplasms (Phase 1)
Cesarean Section (Phase 1)
Child (Phase 4)
Child Behavior (Phase 4)
Cholangiocarcinoma (Phase 4)
Cholangitis (Phase 2)
Choledochal Cyst (Phase 4)
Choledocholithiasis (Phase 4)
Chronic Disease (Phase 4)
Chronic Pain (Phase 3)
Circumcision, Male (Phase 4)
Cocaine-Related Disorders (Phase 1/Phase 2)
Cognition Disorders (Phase 4)
Cognitive Dysfunction (Phase 4)
Colitis, Ulcerative (Phase 4)
Colonic Neoplasms (Phase 4)
Colonic Polyps (Phase 2/Phase 3)
Colonoscopy (Phase 4)
Colorectal Neoplasms (Phase 1)
Communicable Diseases (Phase 1)
Complex Regional Pain Syndromes (Phase 2)
Congenital Abnormalities (Phase 4)
Conscious Sedation (Phase 4)
Coronary Artery Disease (Phase 4)
Cough (Phase 1/Phase 2)
COVID-19 (Phase 1)
Critical Illness (Phase 4)
Crohn Disease (Phase 4)
Cystic Fibrosis (Phase 1)
Cytochrome P-450 CYP3A (Phase 4)
Cytochromes (Phase 1)
Deep Sedation (Phase 4)
Delayed Emergence from Anesthesia (Phase 2)
Delirium (Phase 4)
Dementia (Phase 3)
Dental Anxiety (Phase 4)
Dental Care (Phase 4)
Dental Care for Disabled (Phase 4)
Dental Caries (Phase 4)
Depression (Phase 4)
Depressive Disorder (Phase 4)
Depressive Disorder, Major (Phase 4)
Depressive Disorder, Treatment-Resistant (Phase 4)
Dermatitis, Atopic (Phase 1)
Dermatology (Phase 4)
Dexmedetomidine (Phase 4)
Diabetes Mellitus (Phase 1)
Diabetes Mellitus, Type 2 (Phase 1)
Diagnosis (Phase 3)
Digestive System Diseases (Phase 1)
Drug Interactions (Phase 1)
Drugs, Investigational (Phase 4)
Dyskinesias (Phase 2)
Dyspnea (Phase 2)
Edema (Phase 4)
Electroencephalography (Phase 4)
Emergence Delirium (Phase 4)
Emergencies (Phase 4)
Endometriosis (Phase 1)
Endoscopy (Phase 4)
Endoscopy, Gastrointestinal (Phase 4)
Epilepsy (Phase 4)
Epiretinal Membrane (Phase 4)
Executive Function (Phase 3)
Fatigue (Phase 4)
Fentanyl (Phase 4)
Fertilization in Vitro (Phase 3)
Fibrosis (Phase 4)
Fluoride Poisoning (Phase 3)
Foot Deformities (Phase 4)
Forearm Injuries (Phase 4)
Fractures, Bone (Phase 4)
Gallbladder Diseases (Phase 4)
Gastrectomy (Phase 4)
Gastric Bypass (Phase 4)
Gastrointestinal Stromal Tumors (Phase 1)
General Surgery (Phase 4)
Glucose Metabolism Disorders (Phase 1)
Gout (Phase 4)
Graft Rejection (Phase 4)
Hallucinogens (Phase 1)
Hallux (Phase 4)
Headache (Phase 4)
Health (Phase 1)
Healthy Volunteers (Phase 4)
Heart Diseases (Phase 4)
Heart Failure (Phase 1)
Heart Failure, Systolic (Phase 1)
Hemodynamics (Phase 4)
Hemorrhage (Phase 3)
Hepatic Encephalopathy (Phase 4)
Hepatitis B, Chronic (Phase 1)
Hepatitis C (Phase 1)
Hepatitis C, Chronic (Phase 1)
Hepatitis, Chronic (Phase 4)
Herb-Drug Interactions (Early Phase 1)
Hernia (Phase 4)
Hernia, Inguinal (Phase 4)
Hip Fractures (Phase 4)
Hip Injuries (Phase 4)
HIV (Phase 1)
HIV Infections (Phase 4)
Hodgkin Disease (Phase 1)
Hydrocephalus (Phase 3)
Hydroxyzine (Phase 4)
Hyperalgesia (Phase 4)
Hypercapnia (Phase 1)
Hypertension (Phase 3)
Hypnotics and Sedatives (Early Phase 1)
Hypoadrenocorticism, Familial (Phase 4)
Hypotension (Phase 2)
Hypothermia (Phase 4)
Hysteroscopy (Phase 4)
Immune System Diseases (Phase 4)
Infant, Premature, Diseases (Phase 3)
Infertility (Phase 4)
Inflammation (Phase 3)
Inflammatory Bowel Diseases (Phase 4)
Influenza, Human (Phase 1)
Infusions, Intravenous (Phase 4)
Intensive Care Units (Phase 4)
Intestinal Neoplasms (Phase 4)
Intestinal Pseudo-Obstruction (Phase 4)
Intracranial Hemorrhages (Phase 2)
Intraoperative Complications (Phase 4)
Intubation (Phase 4)
Irritable Bowel Syndrome (Phase 4)
Ischemic Stroke (Phase 4)
Ketamine (Phase 4)
Kidney Diseases (Phase 3)
Kidney Failure, Chronic (Phase 3)
Knee Injuries (Phase 4)
Lacerations (Phase 4)
Laryngoscopy (Phase 4)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 1)
Leukemia, Lymphoid (Phase 4)
Leukemia, Myeloid, Acute (Phase 1/Phase 2)
Liver Cirrhosis (Phase 3)
Liver Diseases (Phase 4)
Low Back Pain (Phase 1)
Lung Diseases (Phase 4)
Lung Neoplasms (Phase 4)
Lymphoma (Phase 3)
Lymphoma, Large-Cell, Anaplastic (Phase 1)
Lymphoma, Non-Hodgkin (Phase 1)
Magnetic Resonance Imaging (Phase 4)
Malaria (Phase 1)
Mastectomy, Radical (Phase 1/Phase 2)
Melanoma (Phase 1)
Memory Disorders (Phase 1)
Meperidine (Phase 4)
Mesothelioma, Malignant (Phase 1)
Metabolic Detoxication, Phase I (Phase 1)
Metabolic Diseases (Phase 4)
Metabolism (Phase 1)
Midazolam (Phase 4)
Mitochondrial Diseases (Phase 1)
Monitoring, Intraoperative (Phase 4)
Movement Disorders (Phase 2)
Multiple Myeloma (Phase 1)
Multiple Sclerosis (Phase 2)
Multiple Sclerosis, Relapsing-Remitting (Phase 3)
Muscular Atrophy, Spinal (Phase 1)
Musculoskeletal Diseases (Phase 4)
Mutation (Phase 1)
Myocardial Infarction (Phase 1)
Myocardium (Phase 4)
Myoclonus (Phase 4)
Myositis Ossificans (Phase 1)
Nausea (Phase 4)
Neck Pain (Phase 1)
Neoplasm Metastasis (Phase 1)
Neoplasms (Phase 4)
Nephrostomy, Percutaneous (Phase 4)
Nerve Block (Phase 4)
Nervous System Diseases (Phase 3)
Neuralgia (Phase 3)
Neurologic Manifestations (Phase 2)
Obesity (Phase 4)
Obesity, Morbid (Phase 4)
Obsessive-Compulsive Disorder (Phase 2)
Only Child (Early Phase 1)
Orthopedic Procedures (Phase 4)
Osteoarthritis (Phase 4)
Osteoarthritis, Knee (Phase 4)
Osteoporosis, Postmenopausal (Phase 1)
Otitis Media (Phase 2/Phase 3)
Otorhinolaryngologic Surgical Procedures (Phase 2)
Oxidative Stress (Phase 4)
Pain (Phase 4)
Pain, Intractable (Phase 2)
Pain, Postoperative (Phase 4)
Pain, Procedural (Phase 3)
Palliative Care (Phase 4)
Pancreatic Neoplasms (Phase 4)
Pancreatitis (Phase 4)
Parkinson Disease (Phase 1)
Patient Satisfaction (Phase 4)
Pediatrics (Phase 4)
Peritonitis (Phase 4)
Persistent Vegetative State (Phase 4)
Personal Satisfaction (Phase 4)
Pharmacokinetics (Phase 4)
Pharmacologic Actions (Phase 1)
Pharmacology (Phase 1)
Poisoning (Phase 3)
Polyps (Phase 4)
Porphyria, Acute Intermittent (Phase 1)
Porphyrias (Phase 1)
Post-Dural Puncture Headache (Phase 2)
Postoperative Care (Phase 2)
Postoperative Cognitive Complications (Phase 4)
Postoperative Complications (Phase 4)
Postoperative Nausea and Vomiting (Phase 4)
Postoperative Period (Phase 4)
Preanesthetic Medication (Phase 4)
Pregnancy Complications (Phase 4)
Pregnancy Trimester, First (Phase 4)
Premedication (Phase 4)
Propofol (Phase 4)
Prostatic Neoplasms (Phase 4)
Pruritus (Phase 4)
Psoriasis (Phase 1)
Psychological Distress (Phase 3)
Psychophysiologic Disorders (Phase 3)
Pulmonary Disease, Chronic Obstructive (Phase 1)
Recurrence (Phase 1)
Remifentanil (Phase 4)
Renal Insufficiency (Phase 1)
Renal Insufficiency, Chronic (Phase 4)
Respiration, Artificial (Phase 4)
Respiratory Distress Syndrome (Phase 4)
Respiratory Insufficiency (Phase 3)
Respiratory Syncytial Virus Infections (Phase 1)
Retinal Detachment (Phase 4)
Retinal Perforations (Phase 4)
Safety (Phase 4)
Schizophrenia (Phase 3)
Seizures (Phase 4)
Self-Injurious Behavior (Phase 1/Phase 2)
Sepsis (Phase 4)
Sevoflurane (Phase 4)
Shock, Septic (Phase 4)
Skin Diseases, Bacterial (Phase 1)
Sleep (Phase 4)
Sleep Apnea, Obstructive (Phase 4)
Sleep Disorders, Intrinsic (Phase 4)
Snoring (Phase 4)
Spinal Puncture (Phase 4)
Spinal Stenosis (Phase 2/Phase 3)
Sports Medicine (Phase 1)
Status Epilepticus (Phase 3)
Stomach Diseases (Phase 2/Phase 3)
Stress Disorders, Post-Traumatic (Phase 3)
Stress Disorders, Traumatic, Acute (Phase 2)
Stroke (Phase 2)
Substance-Related Disorders (Phase 1)
Substance Withdrawal Syndrome (Phase 4)
Sufentanil (Phase 4)
Suicidal Ideation (Phase 4)
Suicide (Phase 3)
Suicide, Attempted (Phase 3)
Surgical Procedures, Operative (Phase 2)
Tobacco Smoking (Early Phase 1)
Tobacco Use Disorder (Phase 1/Phase 2)
Tomography (Phase 4)
Tonsillectomy (Phase 4)
Tonsillitis (Phase 2)
Tooth Abnormalities (Phase 2/Phase 3)
Tooth Extraction (Phase 3)
Transurethral Resection of Prostate (Phase 4)
Trypanosomiasis, African (Phase 1)
Tuberculosis (Phase 2)
Tuberculosis, Multidrug-Resistant (Phase 1)
Tuberculosis, Pulmonary (Phase 2)
Ultrasonography (Phase 4)
Upper Extremity (Phase 4)
Urinary Bladder, Overactive (Phase 1)
Urinary Tract Infections (Phase 1)
Urination Disorders (Phase 4)
Vasomotor System (Phase 1)
Vasospasm, Intracranial (Phase 2)
Ventilation (Phase 4)
Ventilators, Mechanical (Phase 4)
Vision, Ocular (Phase 4)
Vitrectomy (Phase 4)
Vitreous Detachment (Phase 4)
Vitreous Hemorrhage (Phase 4)
Volunteers (Phase 1)
Vomiting (Phase 4)
Voriconazole (Phase 1)
Wounds and Injuries (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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