Active Ingredient History

NOW
  • Now
DEGARELIX (FIRMAGON®) is a synthetic linear decapeptide amide containing seven unnatural amino acids, five of which are D-amino acids. It is a GnRH receptor antagonist. It binds reversibly to the pituitary GnRH receptors, thereby reducing the release of gonadotropins and consequently testosterone. DEGARELIX (FIRMAGON®) is effective in achieving and maintaining testosterone suppression below the castration level of 50 ng/dL and is indicated for the treatment of patients with advanced prostate cancer.   NCATS

  • SMILES: CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(=O)N)cc1)NC(=O)[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc4cccnc4)NC(=O)[C@@H](Cc5ccc(Cl)cc5)NC(=O)[C@@H](Cc6ccc7ccccc7c6)NC(=O)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N8CCC[C@H]8C(=O)N[C@H](C)C(=O)N
  • InChIKey: MEUCPCLKGZSHTA-XYAYPHGZSA-N
  • Mol. Mass: 1632.29
  • ALogP: Missing data
  • ChEMBL Molecules:
More Chemistry
  • Mechanisms of Action:
  • Multi-specific: No
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: No
ac-2nal-4cpa-3pal-ser-4aph(hydroorotyl)-4aph(carbamoyl)-leu-ilys-pro-ala-nh2 | acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ilys-prolyl-alaninamide | asp3550 | degarelix | degarelix acetate | fe200486 | fe 200486 | fe-200486 | fe-200486 (free base) | firmagon | gonax | uglypeptide1

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