vindesine (Eldisine) Report issue

Small molecule Experimental
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Vindesine, also termed Eldisine, is a semisynthetic vinca alkaloid derived from the flowering plant Catharanthus roseus. Like the natural and semisynthetic vinca alkaloids derived from this plant, vindesine is an inhibitor of mitosis that is used as a chemotherapy drug. By inhibiting mitosis, vinedsine blocks the proliferation of cells, particularly the rapidly proliferation cells of certain types of cancer. It is used, generally in combination with other chemotherapeutic drugs, in the treatment of various malignancies such as leukaemia, lymphoma, melanoma, breast cancer, and lung cancer.   Wikipedia

Chemistry

  • SMILES: CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@H]7[C@](O)([C@H](O)[C@]8(CC)C=CCN9CC[C@]67[C@H]89)C(=O)N)C1.OS(=O)(=O)O
  • InChIKey: COFJBSXICYYSKG-FJFFLIEUSA-N
  • Mol. Mass: 852.02
  • ALogP: 2.73
  • ChEMBL Molecules:
    vindesine sulfate  
    vindesine  
    vindesine  
    vindesine sulfate  
More Chemistry

Pharmacology

Alternative names

3-(aminocarbonyl)-o(4)-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine | 3-carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine | compound 112531 | desacetylvinblastine amide | eldisine | videsine | vindelsine | vindesine | vindesine sulfate

Organizations (46)

Research & Development (46)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (17)

Approved Indications (1)


 

Neoplasms

Experimental Indications - Clinical Trial Phases 1-4 (17)


 

Burkitt Lymphoma (Phase 2)

Hodgkin Disease (Phase 1/Phase 2)

Lung Neoplasms (Phase 3)

Lymphoma (Phase 2)

Lymphoma, B-Cell (Phase 2)

Lymphoma, Large B-Cell, Diffuse (Phase 3)

Lymphoma, Large-Cell, Immunoblastic (Phase 3)

Lymphoma, Non-Hodgkin (Phase 3)

Lymphoma, T-Cell (Phase 4)

Lymphoma, T-Cell, Peripheral (Phase 2)

Melanoma (Phase 4)

Neoplasms ()

Neuroblastoma (Phase 3)

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Phase 3)

Precursor Cell Lymphoblastic Leukemia-Lymphoma (Phase 2/Phase 3)

Small Cell Lung Carcinoma (Phase 2)

Tumor Suppressor Protein p53 (Phase 2)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 31
  • # of Trial Organizations: 46

Trials by Phase

Trial Phase Start Date Organizations Indications

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