Active Ingredient History
Hydroxychloroquine possesses antimalarial properties and also exerts a beneficial effect in lupus erythematosus (chronic discoid or systemic) and acute or chronic rheumatoid arthritis. Although the exact mechanism of action is unknown, it may be based on ability of hydroxychloroquine to bind to and alter DNA. Hydroxychloroquine has also has been found to be taken up into the acidic food vacuoles of the parasite in the erythrocyte. This increases the pH of the acid vesicles, interfering with vesicle functions and possibly inhibiting phospholipid metabolism. In suppressive treatment, hydroxychloroquine inhibits the erythrocytic stage of development of plasmodia. In acute attacks of malaria, it interrupts erythrocytic schizogony of the parasite. Its ability to concentrate in parasitized erythrocytes may account for their selective toxicity against the erythrocytic stages of plasmodial infection. As an antirheumatic, hydroxychloroquine is thought to act as a mild immunosuppressant, inhibiting the production of rheumatoid factor and acute phase reactants. It also accumulates in white blood cells, stabilizing lysosomal membranes and inhibiting the activity of many enzymes, including collagenase and the proteases that cause cartilage breakdown. Hydroxychloroquine is used for the suppressive treatment and treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also indicated for the treatment of discoid and systemic lupus erythematosus, and rheumatoid arthritis. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Abortion, Habitual (Phase 4)
Abortion, Induced (Phase 3)
Abortion, Spontaneous (Phase 2)
Acute Coronary Syndrome (Phase 4)
Adenocarcinoma (Phase 1/Phase 2)
Alopecia Areata (Phase 4)
Anesthesia and Analgesia (Phase 2)
Anticoagulants (Phase 2)
Anti-Inflammatory Agents (Phase 4)
Antimalarials (Early Phase 1)
Antiphospholipid Syndrome (Phase 4)
Antirheumatic Agents (Phase 4)
Arteriosclerosis (Phase 2)
Arthralgia (Phase 2)
Arthritis (Phase 2)
Arthritis, Juvenile (Phase 3)
Arthritis, Rheumatoid (Phase 4)
Arthropathy, Neurogenic (Phase 3)
Asymptomatic Diseases (Phase 4)
Asymptomatic Infections (Phase 4)
Atherosclerosis (Phase 4)
Atrial Fibrillation (Phase 4)
Atrial Flutter (Phase 4)
Autoimmune Diseases (Phase 3)
Axial Spondyloarthritis (Phase 4)
beta-Thalassemia (Phase 1/Phase 2)
Bile Duct Neoplasms (Phase 2)
Biliary Tract Neoplasms (Phase 2)
Borrelia Infections (Phase 4)
Brain Neoplasms (Phase 1/Phase 2)
Breast Neoplasms (Phase 2)
Carcinoma, Hepatocellular (Phase 1/Phase 2)
Carcinoma, Non-Small-Cell Lung (Phase 2)
Carcinoma, Renal Cell (Phase 1/Phase 2)
Carcinoma, Transitional Cell (Phase 2)
Cardiomyopathies (Phase 2/Phase 3)
Cardiovascular Diseases (Phase 4)
Cholangiocarcinoma (Phase 2)
Churg-Strauss Syndrome (Phase 4)
Colitis, Ulcerative (Phase 1/Phase 2)
Colonic Neoplasms (Phase 1/Phase 2)
Colorectal Neoplasms (Phase 2)
Communicable Diseases (Phase 2)
Coronary Artery Disease (Phase 4)
Coronary Disease (Phase 2)
Coronavirus (Phase 3)
Coronavirus Infections (Phase 4)
COVID-19 (Phase 4)
Crohn Disease (Phase 2)
Cystic Fibrosis (Phase 1)
Diabetes Mellitus (Phase 2)
Diabetes Mellitus, Type 1 (Phase 2)
Diabetes Mellitus, Type 2 (Phase 2)
Drug Combinations (Phase 4)
Dry Eye Syndromes (Phase 3)
Endothelial Cells (Phase 4)
Enzyme Inhibitors (Early Phase 1)
Esophageal Neoplasms (Phase 2)
Furunculosis (Phase 1/Phase 2)
Gastrointestinal Neoplasms (Phase 2)
General Surgery (Phase 4)
Genital Neoplasms, Female (Phase 2)
Giant Cell Arteritis (Phase 3)
Glioblastoma (Phase 2)
Glioma (Phase 1/Phase 2)
Graft vs Host Disease (Phase 3)
Granulomatosis with Polyangiitis (Phase 4)
Graves Ophthalmopathy (Phase 4)
Health Personnel (Phase 3)
Healthy Volunteers (Phase 2)
Hematologic Neoplasms (Phase 2)
Hepatitis C (Phase 1/Phase 2)
Hepatitis C, Chronic (Phase 1/Phase 2)
Hidradenitis (Phase 1/Phase 2)
Hidradenitis Suppurativa (Phase 1/Phase 2)
HIV (Phase 3)
HIV Infections (Phase 2)
Hospitalization (Phase 3)
Hydroxychloroquine (Phase 4)
Hypertension (Phase 3)
Immunosuppression Therapy (Phase 1)
Inflammation (Phase 4)
Insulin Resistance (Phase 3)
Kidney Diseases (Phase 4)
Kidney Failure, Chronic (Phase 4)
Klatskin Tumor (Phase 2)
Leukemia (Phase 2)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 2)
Leukemia, Myeloid, Acute (Phase 1)
Lichen Planus, Oral (Phase 2)
Liver Cirrhosis (Early Phase 1)
Liver Neoplasms (Phase 2)
Lung Diseases (Phase 3)
Lung Diseases, Interstitial (Phase 2)
Lung Neoplasms (Phase 2)
Lupus Erythematosus, Cutaneous (Phase 4)
Lupus Erythematosus, Systemic (Phase 4)
Lyme Disease (Phase 4)
Lymphangioleiomyomatosis (Phase 1)
Lymphoma, Follicular (Phase 1/Phase 2)
Mastocytosis (Phase 2/Phase 3)
Melanoma (Phase 2)
Methotrexate (Phase 4)
Microscopic Polyangiitis (Phase 4)
Multiple Myeloma (Phase 1/Phase 2)
Multiple Sclerosis (Phase 1/Phase 2)
Multiple Sclerosis, Chronic Progressive (Phase 2)
Muscle Cramp (Early Phase 1)
Mutation (Phase 2)
Myelodysplastic Syndromes (Phase 1/Phase 2)
Myocardial Infarction (Phase 4)
Myocarditis (Phase 2/Phase 3)
Neoplasm Metastasis (Phase 1/Phase 2)
Neoplasms (Phase 2)
Nephritis, Hereditary (Phase 2)
Nursing Homes (Phase 2/Phase 3)
Obesity (Phase 4)
Osteoarthritis (Phase 3)
Osteoarthritis, Knee (Phase 2)
Osteosarcoma (Phase 1/Phase 2)
Ovarian Neoplasms (Phase 2)
Pancreatic Neoplasms (Phase 2)
Pancreatitis, Chronic (Phase 2)
Peripheral Nervous System Diseases (Phase 2)
Peroxisomes (Phase 2)
Pneumonia (Phase 4)
Pneumonia, Pneumocystis (Phase 3)
Pneumonia, Viral (Phase 3)
Porphyria Cutanea Tarda (Phase 2)
Prediabetic State (Phase 4)
Pre-Eclampsia (Phase 3)
Pre-Exposure Prophylaxis (Phase 3)
Pregnancy Complications (Phase 3)
Pregnant Women (Phase 2)
Prostatic Neoplasms (Phase 2)
Pulmonary Surfactants (Early Phase 1)
Purpura, Thrombocytopenic, Idiopathic (Phase 4)
Rectal Neoplasms (Phase 1/Phase 2)
Renal Insufficiency, Chronic (Phase 2)
Respiratory Distress Syndrome (Phase 3)
Respiratory Insufficiency (Phase 3)
Respiratory Tract Infections (Phase 3)
Retinitis Pigmentosa (Phase 1/Phase 2)
Rheumatic Diseases (Phase 1)
Rheumatology (Phase 4)
Sarcoidosis, Pulmonary (Phase 3)
Sarcoma (Phase 2)
Sarcoma, Clear Cell (Phase 1/Phase 2)
SARS-CoV-2 (Phase 4)
Severe Acute Respiratory Syndrome (Phase 3)
Sjogren's Syndrome (Phase 4)
Sleep Apnea Syndromes (Phase 4)
Small Cell Lung Carcinoma (Phase 2)
Spondylitis, Ankylosing (Phase 4)
Therapeutics (Phase 2)
Thrombocytopenia (Phase 3)
Vascular Stiffness (Phase 2)
Virus Diseases (Phase 3)
Zellweger Syndrome (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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